| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a vesicular stomatitis virus (VSV) vector in mammals, that synergistically attenuates the pathogenicity of VSV. <P>SOLUTION: The VSV vector comprises at least two different classes of mutations, in its genome, selected from a group comprising a temperature-sensitive mutation, a point mutation, a gene shuffling mutation, a G-stem mutation, a non-cytopathic M gene mutation, an ambisense RNA mutation, a truncated G gene mutation, a G gene insertion mutation and a gene deletion mutation. The VSV vector is also a genetically modified VSV vector, that includes at least one foreign RNA sequence inserted into or replacing a region of the VSV genome non-essential for replication, and that attenuates the two mutations synergistically the pathogenicity of VSV. <P>COPYRIGHT: (C)2012,JPO&INPIT |
