| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a composition and a method used for increasing bone mineralization. <P>SOLUTION: A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-β binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-β binding protein sclerostin and a TGF-β superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures. <P>COPYRIGHT: (C)2012,JPO&INPIT |
