发明名称 |
Compositions and Methods to Treat Cardiac Pacing Conditions |
摘要 |
The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.
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申请公布号 |
US2011300107(A1) |
申请公布日期 |
2011.12.08 |
申请号 |
US201113096135 |
申请日期 |
2011.04.28 |
申请人 |
SHARMA VINOD;QIU XIAOHONG;MEDTRONIC, INC. |
发明人 |
SHARMA VINOD;QIU XIAOHONG |
分类号 |
A61K31/7088;A61K35/00;A61P9/00;C12N5/10 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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