OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
摘要
Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3' and/or 5'-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
申请公布号
WO2011150408(A2)
申请公布日期
2011.12.01
申请号
WO2011US38459
申请日期
2011.05.27
申请人
AVI BIOPHARMA, INC.;HANSON, GUNNAR, J.;RUDOLPH, ALEXANDER, CHARLES;CAI, BAO, ZHONG;ZHOU, MING;WELLER, DWIGHT, D.
发明人
HANSON, GUNNAR, J.;RUDOLPH, ALEXANDER, CHARLES;CAI, BAO, ZHONG;ZHOU, MING;WELLER, DWIGHT, D.