THERAPEUTIC METHOD AND COMPOSITION

摘要

Live attenuated therapeutic compositions provide a route for effective immune system priming allowing a subject to more effectively combat inevitable exposure to pathogens. Molecular targets for effective attenuation of a pathogen for use in a therapeutic composition are not commonly conserved across species, however, the expression of anchorless surface proteins is conserved across many pathogens allowing for attenuation. Exemplary embodiments provide therapeutic compositions for protection against a wide array of pathogens, and methods for attenuating pathogens to generate the therapeutic compositions.