发明名称 |
TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS |
摘要 |
The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with this, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection. In particular, asymmetric target sequences present in a plurality of HIV strains are disclosed, as well as tailored recombinases capable of combining these sequences (Tre 3.0 and 4.0) and expression vectors encoding them. |
申请公布号 |
WO2011147590(A2) |
申请公布日期 |
2011.12.01 |
申请号 |
WO2011EP02646 |
申请日期 |
2011.05.27 |
申请人 |
HEINRICH-PETTE-INSTITUT;MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.;HAUBER, JOACHIM;CHEMNITZ, JAN;BUCHHOLZ, FRANK;CHUSAINOW, JANET |
发明人 |
HAUBER, JOACHIM;CHEMNITZ, JAN;BUCHHOLZ, FRANK;CHUSAINOW, JANET |
分类号 |
C12N15/867 |
主分类号 |
C12N15/867 |
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