| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing solid state crystallized shaped particle of allotropic organic compound. <P>SOLUTION: The method for producing solid state crystallized shaped particles of allotropic organic compounds includes steps of: (a) creating a mixture consisting essentially of two or more allotropic organic compounds wherein each of the compounds is of mixed crystalline, amorphous, or both crystalline and amorphous form; (b) fabricating the mixture into a plurality of spherical particles; (c) exposing the spherical particles to an atmosphere containing vapors of one or more solvents for each of the allotropic organic compounds for a time sufficient to effect a solid state crystallization of each of the allotropic organic compounds to its most stable crystalline form; and (d) recovering the particles. Additionally, there are provided extraordinarily stable shaped particles of allotropic organic compounds. The particles can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1-1,000 micrometers. The stable shaped particles are particularly well-suited to the production of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization method affords a means for achieving a storage stable crystalline form of the allotropic compound without loss or deterioration of the original particle dimensions. <P>COPYRIGHT: (C)2012,JPO&INPIT |
