发明名称 |
Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
摘要 |
A new class of paromomycin-derived aminoglycosides (Formula I), which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders. |
申请公布号 |
EP2390255(A1) |
申请公布日期 |
2011.11.30 |
申请号 |
EP20110173958 |
申请日期 |
2007.04.10 |
申请人 |
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED |
发明人 |
BAASOV, TIMOR;BEN-YOSEF, TAMAR;NUDELMAN, IGOR;REBIBO-SABBAH, ANNIE;SHALLOM-SHEZIFI, DALIA;HAINRICHSON, MARIANA |
分类号 |
C07H5/06;A61K31/7036;A61P43/00 |
主分类号 |
C07H5/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|