摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to agent for skin bleaching, representing pyrimidyl pyrazole compound of formula (1), where R1, R3, R4 and R6 each independently represents C1-3alkyl and R2 and R5 each independently represents hydrogen atom or C1-3alkyl, or its pharmacologically acceptable salt. Said agent inhibits production of melanin, possesses low cytotoxicity and can be used as bleaching agent for improvement or prevention of pigment spots, freckles, skin darkening, etc. Invention also relates to composition for skin bleaching for external application, which contains effective amount of said pyrimidyl pyrazole compound of formula (1), described in any of items 1-3, or its pharmacologically acceptable salt. Preferable composition represents cosmetic preparation. ^ EFFECT: obtaining agent for skin bleaching. ^ 6 cl, 3 tbl, 17 ex |