| 摘要 |
<p>Disclosed is a method of producing a free nucleoside compound, with the proviso that the compound 2'-deoxy-5-azacytidine (Decitabine) is excluded, by reacting a glycoside donor with a protected nucleoside base, in a suitable anhydrous solvent and in the presence of a catalyst, whereby a blocked nucleoside compound is obtained, and removing the protecting groups from said blocked nucleoside compound in order to obtain the free nucleoside compound, wherein said catalyst is selected from the group comprising salts of an aliphatic sulphonic acid and/or salts of a strong inorganic acid containing a non-nucleophilic anion.</p> |
