发明名称 |
Novel HCV core+1 protein, methods for diagnosis of HCV infections, prophylaxis, and for screening of anti-HCV agents |
摘要 |
The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a nucleotide sequence extending from nucleotide 598 to nucleotide 920 within the core+1 ORF of HCV represented on FIG. 3B. The invention also provides methods for detecting infection by Hepatitis C virus in biological samples, methods of screening compounds which interact with viral propagation in HCV infected cells or screening of compounds impaction on the expression of shorter form core+1 protein and uses of these compounds for the preparation of compositions useful for their anti-viral activities.
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申请公布号 |
US2011287406(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US20100926387 |
申请日期 |
2010.11.15 |
申请人 |
MAVROMARA PENELOPE;VASSILAKI NIKI;INSTITUT PASTEUR HELLENIQUE;INSTITUT PASTEUR |
发明人 |
MAVROMARA PENELOPE;VASSILAKI NIKI |
分类号 |
C12Q1/70;C07H21/04;C07K5/103;C07K7/08;C07K14/18;C07K16/10;C07K16/40;C12N5/10;C12N15/51;C12N15/63;G01N33/53;G01N33/576 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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