USE OF TCO1, MBP1, ATF1 OR RAS1 FOR TREATMENT OF FUNGAL INFECTION

摘要

PURPOSE: An inhibitor of Tco1, Mbp1, Atf1 or Ras1 for manufacturing an antifungal agent is provided to remarkably increase the efficiency of an antifungal agent. CONSTITUTION: An antifungal pharmaceutical composition contains an inhibitor of Tco1, Mbp1, Atf1 or Ras1 of Cryptococcus neoformans. The inhibitor is administered together with nucleic acid synthesis suppressing antifungal agent successively or simultaneously. The antifungal agent is pyrimidine analog, flucytisine. An antifungal complex agent contains the pharmaceutical composition and antifungal agent for suppressing nucleic acid suppression. A composition for screening antifungal agents contains Tco1, Mbp1, Atf1 or Ras1.