| 发明名称 |
MONOMETHYLVALINE COMPOUND CAPABLE OF CONJUGATION TO LIGAND |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide further HER2-directed cancer therapies. <P>SOLUTION: This invention provides auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), which are prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates are active in vitro and in vivo. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2011231131(A) |
申请公布日期 |
2011.11.17 |
| 申请号 |
JP20110181020 |
申请日期 |
2011.08.22 |
| 申请人 |
SEATTLE GENETICS INC |
发明人 |
DORONINA SVETLANA O;SENTER PETER D;TOKI BRIAN E;EBENS ALLEN J;KLINE TONI BETH;POLAKIS PAUL;SLIWKOWSKI MARK X;SPENCER SUSAN D |
| 分类号 |
C07K5/083;A61K38/00;A61K38/06;A61K39/395;A61K47/48;A61P35/00;A61P35/02;A61P43/00;C07K5/103;C07K16/00;C07K16/30;C07K16/46;C07K19/00;C12P21/08 |
主分类号 |
C07K5/083 |
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