Antibodies against human CCN1 and uses thereof

摘要

Method for the recombinant expression of mammalian cell membrane-bound human CCN1 or a CCN1 domain thereof in mammalian cells, characterized in transforming a mammalian host cell with a vector encoding CCN1 or a CCN1 domain thereof C-terminally fused to a mammalian cell transmembrane domain (CCN1 fusion protein), expressing said CCN1 or CCN1 domain fusion protein in said host cell and recovering said membrane bound CCN1 or said CCN1 domain thereof. And use of such membrane bound CCN1 and domain for the generation of antibodies. An antibody against human CCN1 is useful for the treatment of diseases.