COMPOSITION CONTAINING PIAS3 AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER OR IMMUNE DISEASE

摘要

The present invention relates to a composition containing PIAS3 as an active ingredient for the prevention or treatment of cancer or immune disease. More specifically, the present invention relates to a composition containing the PIAS3 gene or an expression protein thereof as an active ingredient for the prevention or treatment of cancer or immune disease, to an immunosuppressant composition, to a method for reducing or inhibiting undifferentiated T cells into Th17 cells using the PIAS3 gene or an expression protein thereof, and to a method for activating regulatory T cells. The PIAS3 according to the present invention is excellent in inhibiting the differentiation of cytotoxic Th17 cells which produce and secrete inflammatory cytokines and in activating regulatory T cells (Tregs) having characteristics that inhibit the function of abnormally activated immune cells and control inflammatory responses. Thus, the PIAS3 may be useful as a pharmaceutical composition or immunosuppressant which may prevent or treat cancer or immune disease caused by the dysregulation of immune responses.