POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE

摘要

The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate) and the polyamine may be selected from ethylenediamine, diethylenetriamine, diaminopentane, tris(2-aminoethyl)amine, tetraethylenepentamine. A composition comprising the polyamine-containing polymer is disclosed and also its use for introduction of an exogenous nucleic acid into a cell. The aminated polymers described have less toxicity and greater transfection efficiency than the existing polymers.