NUCLEIC ACID-CONTAINING LIPID PARTICLES AND RELATED METHODS

摘要

The present invention provides a method for preparing nucleic acid-lipid nanoparticles comprising the cationic lipid DLinKC2-DMA using a microfluidic mixing device, wherein the resulting nucleic acid-lipid nanoparticles exhibit smaller particle diameter and greater core density than nucleic acid-lipid nanoparticles of the same formulation produced b/ the conventional preformed vesicle method