发明名称 |
METHODS FOR RIBOSOMAL SYNTHESIS OF POLYPEPTIDES CONTAINING UNNATURAL N-TERMINAL GROUPS AND APPLICATIONS THEREOF |
摘要 |
The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA.
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申请公布号 |
US2011275119(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
US20070515074 |
申请日期 |
2007.11.13 |
申请人 |
SUGA HIROAKI;MURAKAMI HIROSHI;GOTO YUKI;OHTA ATSUSHI |
发明人 |
SUGA HIROAKI;MURAKAMI HIROSHI;GOTO YUKI;OHTA ATSUSHI |
分类号 |
C12P21/00;C12N9/10 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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