发明名称 |
Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to beclin-1 |
摘要 |
<p>The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.</p> |
申请公布号 |
EP2385071(A1) |
申请公布日期 |
2011.11.09 |
申请号 |
EP20110171075 |
申请日期 |
2009.12.06 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
KIMCHI, ADI;ZALCKVAR, EINAT |
分类号 |
C07K16/28;A61K31/7088;C07K14/47;C07K14/82;C07K16/44;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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