| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an improved transdermal delivery system for rotigotine. <P>SOLUTION: The improved transdermal delivery system (TDS) comprising a support inert to the components of the matrix, a self-adhesive matrix containing rotigotine and a protective foil or sheet to be removed prior to use, characterized in that the TDS consists of a solid or semi-solid semi-permeable polymer (1) wherein rotigotine in its free base form has been incorporated, (2) which is saturated with rotigotine and contains the rotigotine as a multitude of microreservoirs within the matrix, (3) which is highly permeable for the free base of rotigotine, (4) which is impermeable for the protonated form of rotigotine, (5) wherein the maximum diameter of the microreservoirs is less than the thickness of the matrix. The TDS provides enhanced flux of an amine functional agent across the TDS/skin interface. <P>COPYRIGHT: (C)2012,JPO&INPIT |
