METHOD FOR PRODUCING RECOMBINANT COMPLEX ANTIGENS USING NANOPARTICLES OF HUMAN ROTAVIRUS

摘要

The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.