NOVEL HETEROARYL MONOCYCLIC PYRIMIDINE DERIVATIVE

摘要

Disclosed is a heteroaryl monocyclic pyrimidine derivative which is useful as a drug. Specifically disclosed is a pyrimidine derivative represented by formula (I) which is efficacious in preventing and/or treating diseases relating to signal transmission via Toll-like receptor (TLR). In formula (I), A1 and A2 are represented by formula (A) or (B), provided that when A1 is represented by formula (A), A2 is represented by formula (B), and when A1 is represented by formula (B), A2 is represented by formula (A), [wherein X represents C1-8 alkylene or the like; Y represents a hydrogen atom or the like.; Het represents a 5- or 6-membered nitrogen-containing heteroarylene; W represents C1-8 alkylene or the like; Z1 and Z2 represent a hydrogen atom or the like; Z3 and Z4 represent a hydrogen atom or the like; and R1 to R4 represent a hydrogen atom or the like].