POLYSACCHARIDES COMPRISING CARBOXYL FUNCTIONAL GROUPS SUBSTITUTED BY ESTERIFICATION BY A HYDROPHOBIC ALCOHOL

摘要

The invention relates to a polysaccharide which comprises carboxyl functional groups, said polysaccharide being selected from the group of synthetic anionic polysaccharides comprising 1,6 bonds obtained from neutral polysaccharides, on which at least 15 carboxyl functional groups for 100 saccharide units have been grafted, at least one of said carboxyl functional groups being esterified by a hydrophobic alcohol, denoted Ah: said hydrophobic alcohol (Ah) being grafted or bonded to the anionic polysaccharide by an F function, said F function resulting from coupling the carboxylate function of the anionic polysaccharide and the hydroxyl function of the hydrophobic alcohol, the non-substituted carboxyl functions of the anionic polysaccharide being in the form of cation carboxylate, preferably alkaline such as Na+ or K+, wherein F is an ester group, Ah is a hydrophobic alcohol residue, and said polysaccharide comprises carboxyl functional groups which are amphiphilic with neutral pH. The invention also relates to the use of said polysaccharide for preparing pharmaceutical compositions and to pharmaceutical compositions including a polysaccharide and at least one active principle.