NOVEL SALT OF BIGUANIDE COMPOUNDS, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS

摘要

PURPOSE: A novel salt of a biguanide compound is provided to ensure excellent anticancer effects and the same AMPK activity as metformin hydrochlorides, and excellent blood glucose decrease effects, and antioxidant effects. CONSTITUTION: A novel salt of a biguanide compound has the structure of chemical formula 1. A method for preparing the acid addition salts of the biguanide compound comprises a step of reacting the free base of the biguanide compound represented by chemical formula 5 with glyphosate. In chemical formula 1, R1 or R2 are independently hydrogen, C1-4 alkyl, and phenyl-substituted C1-4 alkyl; and A is glyphosate. The free base of the biguanide compound reacts with 0.5-4 mole equivalent of glyphosate per 1 molar equivalent.