NOVEL DRY POWDER INHALATION SYSTEM FOR TRANSPULMONARY ADMINISTRATION

摘要

It is intended to provide a novel dry powder inhalation system for transpulmonary administration which is suitable for transpulmonary administration. This novel dry powder inhalation system for transpulmonary administration comprises : (1) a container having a freeze-dried composition for transpulmonary administration which is prepared by freeze-drying a liquid composition containing a component in an undissolved state and has the following properties (i) to (iii): (i) being in the form of a non-powdery cake; (ii) having a disintegration index of 0.05 or more; and (iii) upon an air impact of an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec, being disintegrated into fine particles having an average particle diameter (an aerodynamic particle diameter) of 10 µm or less or an effective particle rate of 10% or more; combined with (2) a means of applying the above-described air impact to the freeze-dried composition in the above-described container, and a means of discharging the powdery freeze-dried composition having been disintegrated into fine particles.