发明名称 Modified HIV-1 clade C envelope glycoprotein immunogens comprising deletions in the gp120/gp41 cleavage site and gp41 fusion domain
摘要 The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
申请公布号 US8048431(B2) 申请公布日期 2011.11.01
申请号 US20070896934 申请日期 2007.09.06
申请人 DUKE UNIVERSITY 发明人 HAYNES BARTON F.
分类号 A61K39/21 主分类号 A61K39/21
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