NUCLEIC ACID MOLECULE OF A BIOSYNTHETIC CLUSTER ENCODING NON RIBOSOMAL PEPTIDE SYNTHASES AND USES THEREOF

摘要

The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I′). The present invention also provides a method of preparing a compound of formula (I) or (I′) or of formula (II) to (VII), (XI) to (XIV) and (XVII) and (XVIII). Moreover, the use of such compound as a pharmaceutical composition is also provided in the present invention.