发明名称 |
Process for the preparation of olmesartan medoxomil |
摘要 |
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.
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申请公布号 |
US8048904(B2) |
申请公布日期 |
2011.11.01 |
申请号 |
US20070305512 |
申请日期 |
2007.06.15 |
申请人 |
MATRIX LABORATORIES LTD. |
发明人 |
RAMANJANEYULU GORANTLA SEETA;MOHAN BANDARI;RAY PURNA CHANDRA;SETHI MADHURESH KUMAR;RAWAT VIJENDRA SINGH;KRISHNA YERRAMALLA RAJA;LAKSHMINARAYANA VEMULA;SRINIVAS MAMIDI |
分类号 |
A61K31/41;C07D405/14 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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