COMPOSITIONS AND METHODS FOR SELECTIVELY PRODUCING SIRNA
摘要
The disclosure provided herein provides compositions and methods for producing siRNA. Also disclosed are compositions and methods for modulating the production of siRNA. Also disclosed herein are compositions and methods of treating a disease in a subject comprising administering a Dicer enzyme comprising a helicase domain or a mutated Dicer enzyme to a subject. Also disclosed herein are methods of screening for a candidate modulator that modulates siRNA production.
申请公布号
WO2011133878(A2)
申请公布日期
2011.10.27
申请号
WO2011US33600
申请日期
2011.04.22
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;WELKER, NOAH, C.;MAITY, TUHIN, S.;ARUSCAVAGE, PHILLIP, JOSEPH, JR;BASS, BRENDA, L.
发明人
WELKER, NOAH, C.;MAITY, TUHIN, S.;ARUSCAVAGE, PHILLIP, JOSEPH, JR;BASS, BRENDA, L.