发明名称 |
COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES |
摘要 |
The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes. |
申请公布号 |
CA2796722(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
CA20112796722 |
申请日期 |
2011.04.19 |
申请人 |
NLIFE THERAPEUTICS, S.L. |
发明人 |
MONTEFELTRO, ANDRES PABLO;ALVARADO URBINA, GABRIEL;BORTOLOZZI BIASSONI, ANALIA;ARTIGAS PEREZ, FRANCESC;VILA BOVER, MIQUEL |
分类号 |
A61K47/48;A61K49/00;A61K49/12;A61P25/00;C12N15/11 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|