COMPOSITION FOR TREATMENT OF ACUTE PSEUDOMEMBRANOUS COLITIS

摘要

Disclosed is a composition for treatment of pseudomembranous colitis including a coprisin peptide derivative CopA3 (HL) having the following amino acid sequence, as an active ingredient: L-L-C-A-L-R-K-K. According to the present disclosure, the coprisin peptide derivative CopA3 (HL) does not show antibiotic effects upon effective colon microorganisms such as Bifidobacterium, Lactobacillus, or the like, while having antibiotic effects specific to Cd bacteria as a pathogenic microorganism. Effects of CopA3 (HL) for inhibiting growth of Cd bacteria have been verified through animal testing, and Cd bacteria-derived intestinal inflammation and villous necrosis processes are effectively relieved.