PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS
摘要
<p>There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1- naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-i-naphthylethylamine or a salt of (R)-i-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.</p>
申请公布号
WO2010100429(A8)
申请公布日期
2011.10.20
申请号
WO2010GB00392
申请日期
2010.03.04
申请人
CIPLA LIMITED;KANKAN, RAJENDRA, NARAYANRAO;RAO, DHARMARAJ, RAMACHANDRA;BIRARI, DILIP, RAMDAS;CURTIS, PHILIP, ANTHONY