发明名称 |
Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
摘要 |
<p>Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer as disclosed. In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. In an alternate embodiment, human dendritic cells are exposed to a prostate cancer antigen or specific antigenic peptide in vitro and incubated or cultured with primed or unprimed T cells to activate the relevant T cell responses in vitro. The activated T cells are then administered to a prostate cancer patient. Methods and compositions for human dendritic cells with extended life span and cryopreserved dendritic cells are disclosed.</p> |
申请公布号 |
EP2377548(A2) |
申请公布日期 |
2011.10.19 |
申请号 |
EP20100183831 |
申请日期 |
1996.07.29 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
MURPHY, GERALD P.;BOYNTON, ALTON L.;TJOA, BENJAMIN A. |
分类号 |
A61K39/00;A61K35/12;A61K35/14;A61K35/26;A61K35/55;A61K38/04;A61P13/08;A61P35/00;A61P37/04;C07K7/00;C07K7/06;C07K14/705 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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