发明名称 Compound having S1P receptor binding potency and use thereof
摘要 Provided are: a compound represented by formula (I): (wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain; L represents a hydrogen atom or a substituent; X represents amino which may have a substituent(s), or a heterocyclic group which contains at least one nitrogen atom and which may have a substituent(s); n represents 0 to 3, in which when n is 2 or more, a plurality of ring A's may be the same or different from one another); a salt thereof; an N-oxide form thereof; a solvate thereof, a prodrug thereof; and a medicament which includes those. The compound represented by formula (I) is capable of binding S1P receptors (in particular, EDG-1 and/or EDG-6), and useful for preventing and/or treating rejection in transplantation, autoimmune diseases, allergic diseases, etc.
申请公布号 US8039674(B2) 申请公布日期 2011.10.18
申请号 US20050630658 申请日期 2005.06.22
申请人 ONO PHARMACEUTICAL CO., LTD. 发明人 HABASHITA HIROMU;NAKADE SHINJI
分类号 C07C211/00;A01N47/10;A61K31/27;C09B11/02 主分类号 C07C211/00
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