The invention describes a method for isolating one or more genetic elements encoding a gene product having a desire activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
申请公布号
AT527381(T)
申请公布日期
2011.10.15
申请号
AT20050792245T
申请日期
2005.10.10
申请人
MEDICAL RESEARCH COUNCIL;THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE