| 摘要 |
The invention relates to a method for producing crystalline active ingredient particles, wherein the active ingredient is crystallized from a supersaturated solution on the surface of particles of the active ingredient, wherein a suspension of active ingredient particles is subjected to wet grinding in a supersaturated solution of the active ingredient in a first module, at least one part of the suspension of active ingredient particles is cooled in a second module and simultaneously subjected to ultrasound, the active ingredient particle suspension from the first module is fed into the second module, and the active ingredient particle suspension is fed back into the first module after cooling and being subjected to ultrasound, wherein active ingredient solution and optionally antisolvent are added to the suspension and active ingredient particles and liquid phase are extracted, wherein the relative supersaturation of the active ingredient in the liquid phase of the suspension, relative to the entire liquid phase, is = 90 % , and the extracted active ingredient particles comprise a mean particle size d50 of 10 - 500 µm. |
