MICRORNA-CONTROLLED RECOMBINANT VACCINIA VIRUS AND USE THEREOF

摘要

Provided is a vaccinia virus which grows specifically in cancer cells and destroys the cancer cells. Also provided is utilization of said virus in cancer therapy. The vaccinia virus is a microRNA-regulated vaccinia virus which carries the target sequence of a microRNA, said microRNA showing reduced expression in cancer cells compared with in normal cells, having been inserted into the 3'-untranslated region of B5R gene participating in virus growth, grows specifically in the aforesaid cancer cells, and exhibits a tumorlytic action of destroying the cancer cells.