发明名称 |
Modified release compositions comprising tacrolimus |
摘要 |
A modified release composition comprising tacrolimus releases less than 20% w/w of the active ingredient within 0.5 hours when subjected to an in vitro dissolution test using USP Paddle method and using 0.1 N HCl as dissolution medium and has increased bioavailability by effectively reducing or even avoiding the effects of CYP3A4 metabolism. The modified composition may be coated with an enteric coating; and/or may comprise a solid dispersion or a solid solution of tacrolimus in a hydrophilic or water-miscible vehicle and one or more modifying release agents; and/or may comprise a solid dispersion or a solid solution of tacrolimus in an amphiphilic or hydrophobic vehicle and optionally one or more modifying release agents.
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申请公布号 |
US2011251231(A1) |
申请公布日期 |
2011.10.13 |
申请号 |
US201113167095 |
申请日期 |
2011.06.23 |
申请人 |
LIFECYCLE PHARMA A/S |
发明人 |
HOLM PER;NORLING TOMAS |
分类号 |
A61K31/439;A61K9/16;A61K9/20;A61K31/436;A61P31/04;A61P37/06;C07D498/18 |
主分类号 |
A61K31/439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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