发明名称 |
SPRAY-DRIED CRYSTALLINE ACTIVE INGREDIENT |
摘要 |
A process for preparing a spray-dried product for improving the rate of dissolution of the active ingredient comprises the steps of (i) mixing a crystalline active ingredient, which has a dissolution rate in unstirred water at 25°C of greater than 15 minutes at a concentration of 14ppm of the active ingredient, with a starch derivative, a second carrier material, and optionally xanthan gum to form a suspension, dispersion or solution of the active ingredient, (ii) homogenizing the mixture at a pressure of at least 4000 psig (2.758 x 107Pa), and (iii) spray-drying the homogenized mixture, the spray- dried active ingredient having an increased dissolution rate in water compared to the unencapsulated active ingredient. |
申请公布号 |
WO2011121515(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
WO2011IB51294 |
申请日期 |
2011.03.28 |
申请人 |
FIRMENICH SA;GREGSON, CHRISTOPHER M.;SKIFF, RONALD H.;TRIOLO, FERDINAND M. |
发明人 |
GREGSON, CHRISTOPHER M.;SKIFF, RONALD H.;TRIOLO, FERDINAND M. |
分类号 |
A23L1/00;A23L1/22;A61K8/11;A61K9/14 |
主分类号 |
A23L1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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