发明名称 |
ANTIBODIES AGAINST CSF-1R |
摘要 |
The invention provides a human antibody that binds human CSF-IR with high affinity. Antibodies of the present invention have significant advantages over the antibodies known in the art by being multifunctional : inhibiting signaling of CSF-1R, internalizing and inducing CSF-1R degradation and stimulating ADCC in cell including tumors, macrophages and monocytes. They are also shown to be effective in treating leukemia, breast, endometrial and prostate cancer alone or in combination with docetaxel, paclitaxel, Herceptin® or doxorubicin. |
申请公布号 |
WO2011123381(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
WO2011US30148 |
申请日期 |
2011.03.28 |
申请人 |
IMCLONE LLC;DOODY, JACQUELINE, FRANCOISE;LI, YANXIA |
发明人 |
DOODY, JACQUELINE, FRANCOISE;LI, YANXIA |
分类号 |
C07K16/28;A61K39/395;A61P35/00;A61P35/02;C07K16/32 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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