| 发明名称 |
THALIDOMIDE ANALOGS |
| 摘要 |
Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
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| 申请公布号 |
US2011245210(A1) |
申请公布日期 |
2011.10.06 |
| 申请号 |
US201113153355 |
申请日期 |
2011.06.03 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF;THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
GREIG NIGEL H.;HOLLOWAY HAROLD;BROSSI ARNOLD;ZHU XIAOXIANG;GIORDANO TONY;YU QIAN-SHENG;FIGG WILLIAM D. |
| 分类号 |
A61K31/625;A61K31/4035;A61K31/437;A61K31/4439;A61K31/538;A61P35/00;C07D209/44;C07D209/46;C07D209/50;C07D211/84;C07D211/86;C07D211/88;C07D401/04;C07D413/04;C07D471/04 |
主分类号 |
A61K31/625 |
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