发明名称 |
MICRORNA COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYELOGENOUS LEUKEMIA |
摘要 |
The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.
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申请公布号 |
US2011244024(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
US20080672715 |
申请日期 |
2008.08.11 |
申请人 |
BRITISH COLUMBIA CANCER AGENCY BRANCH |
发明人 |
KUCHENBAUER FLORIAN;HEUSER MICHAEL;HUMPHRIES RICHARD KEITH |
分类号 |
A61K9/127;A61K31/7088;A61K35/12;A61P35/02;B82Y5/00;C12N15/113;C12Q1/68 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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