发明名称 |
METHODS FOR DETERMINING COPY NUMBER VARIATIONS |
摘要 |
The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions.
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申请公布号 |
US2011245085(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
US20100958352 |
申请日期 |
2010.12.01 |
申请人 |
RAVA RICHARD P;RHEES BRIAN KENT |
发明人 |
RAVA RICHARD P.;RHEES BRIAN KENT |
分类号 |
C40B30/00;C12Q1/68 |
主分类号 |
C40B30/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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