发明名称 |
Genus-Wide Chlamydial Peptide Vaccine Antigens |
摘要 |
Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis.
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申请公布号 |
US2011236484(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US200913120071 |
申请日期 |
2009.09.21 |
申请人 |
WAYNE STATE UNIVERSITY |
发明人 |
WHITTUM-HUDSON JUDITH;HUDSON ALAN P. |
分类号 |
A61K9/00;A61K39/00;A61K39/12;A61P31/04;A61P37/04;C07H21/00;C07K7/06;C07K7/08;C07K7/64;C07K14/00;C12N15/63 |
主分类号 |
A61K9/00 |
代理机构 |
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