| 摘要 |
<p>The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</p> |
| 申请人 |
ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC |
发明人 |
GIJSEN, HENRICUS, JACOBUS, MARIA;VELTER, ADRIANA, INGRID;MACDONALD, GREGOR, JAMES;BISCHOFF, FRANCOIS, PAUL;WU, TONGFEI;VAN BRANDT, SVEN, FRANCISCUS, ANNA;SURKYN, MICHEL;ZAJA, MIRKO;PIETERS, SERGE, MARIA, ALOYSIUS;BERTHELOT, DIDIER, JEAN-CLAUDE;DE CLEYN, MICHEL, ANNA, JOZEF;OEHLRICH, DANIEL |
