Metabolites of tricyclic amides useful for inhibition of G-protein function and methods of treatmentof proliferative diseases

摘要

The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I): and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R₁ is selected from the group consisting of H and -O; R₂-R₅ can be the same or different, each being independently selected from the group consisting of H, -OH, halide, -NH₂ and -O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when, the double bonds are not adjacent, and when 0, one of R₁-R₅ is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.