PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING
摘要
Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
申请公布号
EP2368120(A1)
申请公布日期
2011.09.28
申请号
EP20090774804
申请日期
2009.12.16
申请人
E. I. DU PONT DE NEMOURS AND COMPANY
发明人
CHENG, QIONG;FAHNESTOCK, STEPHEN, R.;HE, HONGXIAN;KOSTICHKA, KRISTY, N.;WANG, HONG