发明名称 |
HUMAN ANTIBODIES TO HUMAN CD20 AND METHOD OF USING THEREOF |
摘要 |
<p>A human antibody or antigen-binding fragment of an antibody that specifically binds human CD20 and is capable of inducing complement dependent cytotoxicity (CDC), and is capable of increasing symptom free survival time between about 2-fold to about 9-fold or more, relative to control-treated animals in a mouse model of human lymphoma. The antibody or antigen-binding fragment thereof is useful in a therapeutic method for treating a CD20-mediated disease or condition, such as for example, non-Hodgkin's lymphoma, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic lymphocytic leukemia, and inflammatory diseases.</p> |
申请公布号 |
TN2010000054(A1) |
申请公布日期 |
2011.09.26 |
申请号 |
TN20100000054 |
申请日期 |
2010.01.29 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MARTIN, JOEL H.;ANG, LI-HSIEN;STEVENS, SEAN;ALLISON, ERIN M. |
分类号 |
A61K39/395;A61P35/00;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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