发明名称 |
SYNTHESIS OF (PHENYLALKYLOXY)PHENYL-OXOBUTANOIC ACIDS |
摘要 |
<p>A method for synthesizing (phenylalkyloxy)phenyl-oxobutanoic acid compounds is described. The corresponding (phenylalkyloxy)acylphenyl compound is halogenated, giving the alpha haloketone. The halide is displaced by the anion of a di-alkyl malonate to give a substituted malonic ester. Hydrolysis of the ester and decarboxylation of the diacid gives the desired product.</p> |
申请公布号 |
EP2365746(A1) |
申请公布日期 |
2011.09.21 |
申请号 |
EP20090825305 |
申请日期 |
2009.11.03 |
申请人 |
WELLSTAT THERAPEUTICS CORPORATION |
发明人 |
WIRTH, DAVID D.;HUDSPETH, JAMES, P. |
分类号 |
A01N37/10;C07C51/09;C07C51/38 |
主分类号 |
A01N37/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|