PREPARATION OF CABERGOLINE FORM I FROM A SOLVATE OF CABERGOLINE AND ETHYLBENZENE

摘要

The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed is a method for preparing cabergoline form I by combining cabergoline and a fist solvent to form a solution and additionally including a second solvent to the solution, followed by crystallisation to form cabergoline form I. Further disclosed is a solvate form of cabergoline comprising cabergoline and ethylbenzene and, optionally, n-heptane. (see formula I)